The study demonstrates that AI virtual patients, such as DDx, significantly enhance early clinical reasoning skills and self-confidence among first-year medical students, with an overall improvement of 48% and even greater gains in diagnostic interpretation and physical exam reasoning. By integrating LLM-driven, small-group simulations into pre-clerkship curricula, DDx provided a scalable, interactive, and engaging alternative to traditional SP encounters, fostering real-time feedback and structured diagnostic thinking.
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